As young adults, Betty and Wilma Flintstone were employed as cigarette girls/waitresses at a resort. There, they first met, and fell in love with their future husbands, Fred Flintstone and Barney Rubble. Eventually, Betty and Barney were married, presumably not long after Fred and Wilma.
Betty became a homemaker, keeping house with such prehistoric aids as a baby mammoth vacuum cleaner, pelican washing machine, and so forth. Betty, much like Wilma, also enjoyed volunteering for various charitable/women's organizations in Bedrock, shopping, and (occasionally) meeting the celebrities of their world, including "Stony Curtis", "Cary Granite", and "Ann-Margrock". Betty and Barney later found an abandoned infant on their doorstep, by the name of "Bamm-Bamm." After a court battle for possession of Bamm-Bamm (in which the Rubbles faced the opposition's noted prehistoric lawyer "Perry Masonry"), the couple were allowed to adopt Bamm-Bamm. The Rubbles never had biological children.
When Bamm-Bamm was a teenager, Betty gained employment as a reporter for one of Bedrock's newspapers, the Daily Granite, under the editorial guidance of Lou Granite. While employed there, she shared various adventures with prehistoric superhero Captain Caveman, who (in a secret identity) also works for the newspaper.
Later still, after Bamm-Bamm grew up and left home, Betty started a successful catering business with her neighbor and friend Wilma, before becoming a grandmother to Bamm-Bamm's twin children, Chip and Roxy.