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Spider-Gwen is a character that appears in LEGO Spider-Man: The Videogame.
Gwen Stacy was bitten by a Radioactive Spider, and became the amazing Spider-Woman. In one of her adventures, she faced the mutated Peter Parker, who turned himself into a Lizard-like creature in an attempt to be "special" like Gwen, and died in the aftermath. She was then wanted by the authorities and her father, who was the head of the New York Police Department, because of Parker's death.
Gwen was one of the first spider-totems to join Spider UK's Spider-Army in order to combat the Inheritors during the Great Hunt. She was sent to Earth-21205 to recruit the spider-totem of that reality, a Peter Parker who was driven to madness and grief caused by the death of the Gwen of that reality and became the Goblin. However, that Peter was killed by Verna and her Hounds. Angered, Gwen swore vengeance and warped away from that reality. Spider-Woman was later present during the final fight agains the Inheritors, during which the villians were finally defeated and dealt with.
Gwen later returned to her reality, where she still tried to turn the public opinion against her by becoming a vigilante. With the appearance of a new villain named the Vulture, Gwen set out to catch him and deliver him to the police, in order to gain their trust.